Peptide Synthesis Lab
Indian Institute of Technology, Kanpur
Publications
2026
Organogelation to Hydrogelation: Effect of C-Terminal functionalization of Peptides. Sumedha Gupta, Nikita Jain, Ramesh Ramapanicker; Journal of Peptide Science 2026, 32:e70102; https://doi.org/10.1002/psc.70102
Multifunctional Amphicharged Surfactants: Unraveling pH and Thermal Modulation of Their Interactions with Bovine Serum Albumin. Sumedha Gupta, Neelakshi, Nikita Jain, Ramesh Ramapanicker; Langmuir 2026, 42, 17, 12108–12124; https://doi.org/10.1021/acs.langmuir.6c00589
Modification of the Phenylalanine Residue and Its Effects on Peptide Hydrogelation. Sumedha Gupta, Vikrant Vini, Nikita Jain, Ramesh Ramapanicker, Peptide Science 2026, 118: e70032; https://doi.org/10.1002/pep2.70032
Total Synthesis of Koshidacin A: Payne Rearrangement- Driven Enantioselective Construction of the Side Chain Triol Unit. Preeti Kapri, Devki Nandan, Ramesh Ramapanicker; European Journal of Organic Chemistry 2026, e202500975; https://doi.org/10.1002/ejoc.202500975
2025
Design and Syntheses of Amphicharged Bolaamphiphilic Molecules from L-Lysine and L-Glutamic Acid. Neelakshi Neelakshi, Ankita Singh, and Ramesh Ramapanicker; ChemistrySelect 2025, 10, e00922; https://doi.org/10.1002/slct.202500922
Peptide Stapling Using Sonogashira Coupling. Devki Nandan, Susanta Kumar Behera, and Ramesh Ramapanicker; ChemBioChem 2025, 26, e2025000; https://doi.org/10.1002/cbic.2025000
N-lauroylglutamates with two and four carboxylate head groups: Their interactions with bovine serum albumin. Ankita Singh, Sumedha Gupta, Neelakshi, Vinithra Gurunarayanan, and Ramesh Ramapanicker; J Surfact Deterg. 2025;28:501–510; https://doi.org/10.1002/jsde.12818
Crystallographic Analysis of Short Helical Peptides Containing Homologs of Phenylalanine. Mrinal Kalita, Archana, Ramesh Ramapanicker, and Prema G. Vasudev; Journal of Peptide Science, 2025; 31:e3667; https://doi.org/10.1002/psc.3667
Microscopic growth of pyridinium oxime based amphipathic on graphite: Effect of relative position of substituents. Poonam Chauhan, Prithwidip Saha, Thiruvancheril G. Gopakumar, and Ramesh Ramapanicker; J Surfact Deterg. 2025;28:123–132; https://doi.org/10.1002/jsde.12783
Enhancing the electronic-coupling and conductivity of a monolayer film of ferrocenyl molecules by Pd and Cu doping. Sunny M. P. Gautam, Himani Malik, Vikash Meghwal, Sruthi Manoharan, Vinithra Gurunarayanan, Ramesh Ramapanicker and Thiruvancheril G. Gopakumar; J. Mater. Chem. C, 2025,13, 4180-4190; https://doi.org/10.1039/D4TC04978K
2024
Incorporation of phenylcarbonyl groups in the sidechain: A tool to induce ordered assembly of peptides on surfaces. Mrinal Kalita, Khushboo Yadav, Archana Archana, Thiruvancheril G. Gopakumar, Prema G. Vasudev, and Ramesh Ramapanicker; J Pept Sci. 2024;30:e3629; https://doi.org/10.1002/psc.3629
From trash to treasure: Cattle manure as a potent green corrosion inhibitor. Saikat Mandal, Debdipta Banik, Shreyasi Banik, Devki Nandan, R. Ramapanicker, Raju K. Gupta, K. Mondal; Bioresource Technology Reports 26 (2024) 101841; https://doi.org/10.1016/j.biteb.2024.101841
2023
Enhancing Photocatalytic Attributes of Perovskite Nanocrystals in Aqueous Media via Ligand Engineering. Monika Ahlawat, Neelakshi, Ramesh Ramapanicker, Vishal Govind Rao; ACS Appl. Mater. Interfaces 2024, 16, 1, 623–632; https://doi.org/10.1021/acsami.3c14321
Enhanced Stability and Energy Transfer in Perovskite Nanocrystals: Paving the Way for Moisture-Resistant Light-Harvesting Devices. Pooja Aggarwal, Anubhab Halder, Neelakshi, Ramesh Ramapanicker, Vishal Govind Rao; ACS Appl. Nano Mater. 2023, 6, 23, 21616–21625; https://doi.org/10.1021/acsanm.3c03600
Binding Strength-Guided Shuttling of Charge Carriers from Perovskite Nanocrystals to Molecular Acceptors. Siddharth Singh, Diksha Mittal, Vinithra Gurunarayanan, Ankita Sahu, Ramesh Ramapanicker, Vishal Govind Rao; ACS Appl. Energy Mater. 2023, 6, 15, 8091–8101; https://doi.org/10.1021/acsaem.3c01193
Design Principle of a Water-Dispersed Photocatalytic Perovskite through Ligand Deconstruction. Monika Ahlawat, Neelakshi, Ramesh Ramapanicker, Vishal Govind Rao; ACS Energy Lett. 2023, 8, 5, 2159–2168; https://doi.org/10.1021/acsenergylett.3c00532
Energy Funneling from Water-Dispersed Perovskites to Chromophores. Pooja Aggarwal, Anubhab Halder, Neelakshi, Ramesh Ramapanicker, Vishal Govind Rao; ACS Energy Lett. 2023, 8, 3, 1520–1528; https://doi.org/10.1021/acsenergylett.3c00197
2022
Perovskite photocatalysis: realizing long-lived charge-separated states at the interface of CsPbBr3 nanocrystals and functionalized ferrocene molecules. Siddharth Singh, Diksha Mittal, Vinithra Gurunarayanan, Ankita Sahu, Ramesh Ramapanicker, Vishal Govind Rao; J. Mater. Chem. A, 2022,10, 21112-21123; https://doi.org/10.1039/D2TA05692E
2021
Amphiphilic conjugates of ferrocene with amino acids and peptides: Design, synthesis, and studies on their aggregation behavior. Vinithra Gurunarayanan, Ramesh Ramapanicker; Journal of Peptide Science 2021, 27:e3332; https://doi.org/10.1002/psc.3332
Asymmetric synthesis of six tetrahydroisoquinoline natural products through α-amination of an aldehyde. Anas Ansari , Amol B. Gorde, Ramesh Ramapanicker; Tetrahedron 2021, 88, 132121; https://doi.org/10.1016/j.tet.2021.132121
Asymmetric Michael addition reactions of aldehydes to β-nitrostyrenes catalyzed by (S)–N-(D-prolyl-L-prolyl)-1 -triflicamido-3 -phenylpropan-2-amine. Anas Ansari , Amol B. Gorde, Ramesh Ramapanicker; Tetrahedron 2021, 87, 132095; https://doi.org/10.1016/j.tet.2021.132095
2020
Revealing the Limits of Intermolecular Interactions: Molecular Rings of Ferrocene Derivatives on Graphite Surface. Prithwidip Saha, Vivek Kumar Yadav, Vinithra Gurunarayanan, Ramesh Ramapanicker, Jayant K. Singh, Thiruvancheril G. Gopakumar; J. Phys. Chem. Lett. 2020, 11, 1, 297–302; https://doi.org/10.1021/acs.jpclett.9b03357
2019
Enantioselective Michael Addition of Aldehydes to β-Nitrostyrenes Catalyzed by (S)-N-(D-Prolyl)-1-triflicamido-3-phenylpropan-2-amine. Amol B. Gorde, Ramesh Ramapanicker; European Journal of Organic Chemistry 2019, 29, 4745-4751; https://doi.org/10.1002/ejoc.201900719
Understanding the Adsorption Energetics of Growth Polymorphs of Ferrocene Derivatives: Microscopic Thermal Desorption Analysis. Prithwidip Saha, Vivek Kumar Yadav, Vinithra Gurunarayanan, Ramesh Ramapanicker, Jayant K. Singh, Thiruvancheril G. Gopakumar; J. Phys. Chem. C 2019, 123, 30, 18488–18494; https://doi.org/10.1021/acs.jpcc.9b05557
Synthesis of peptides containing oxo amino acids and their crystallographic analysis. Mrinal Kalita, Archana Archana, Astha Dimri, Prema G. Vasudev, Ramesh Ramapanicker; Journal of Peptide Science 2019, 25, e3148; https://doi.org/10.1002/psc.3148
d-Prolyl-2-(trifluoromethylsulfonamidopropyl)pyrrolidine: An Organocatalyst for Asymmetric Michael Addition of Aldehydes to β-Nitroalkenes at Ambient Conditions. Amol B. Gorde, Ramesh Ramapanicker; J. Org. Chem. 2019, 84, 3, 1523–1533; https://doi.org/10.1021/acs.joc.8b02945
2018
Enantioselective Synthesis of (R)-Antofine and (R)-Cryptopleurine. Anas Ansari, Dr. Ramesh Ramapanicker; ChemistrySelect 2018, 3, 12591 – 12594; https://doi.org/10.1002/slct.201803529
Selection of Adlayer Patterns of 1,3-Dithia Derivatives of Ferrocene by the Nature of the Solvent. Prithwidip Saha, Vinithra Gurunarayanan, Vladimir V. Korolkov, Prema G. Vasudev, Ramesh Ramapanicker, Peter H. Beton, Thiruvancheril G. Gopakumar; J. Phys. Chem. C 2018, 122, 33, 19067–19074; https://doi.org/10.1021/acs.jpcc.8b06036
Enantioselective Synthesis of 2-Aminomethyl and 3-Amino Pyrrolidines and Piperidines through 1,2-Diamination of Aldehydes. Anas Ansari, Ramesh Ramapanicker; J. Org. Chem. 2018, 83, 15, 8161–8169; https://doi.org/10.1021/acs.joc.8b00933
A bromo-capped diruthenium(I,I) N-heterocyclic carbene compound for in situ bromine generation with NBS: catalytic olefin aziridination reactions. Gargi Sengupta, Pragati Pandey, Subhabrata De, Ramesh Ramapanicker, Jitendra K. Bera; Dalton Trans 2018, 47, 11917-11924; https://doi.org/10.1039/C8DT01851K
2017
Diastereoselective synthesis of D-threo-sphinganine, L-erythro-sphinganine and (−)-spisulosine through asymmetric α-hydroxylation of a higher homologue of Garner's aldehyde. Vipin Kumar Jain, Ramesh Ramapanicker; Tetrahedron 2017, 73, 1568e1575; https://doi.org/10.1016/j.tet.2017.02.001
Click Chemistry Route to the Synthesis of Unusual Amino Acids, Peptides, Triazole-Fused Heterocycles and Pseudodisaccharides. Srinivasan Chandrasekaran, Ramesh Ramapanicker; Chem. Rec. 2017, 17, 63 – 70; https://doi.org/10.1002/tcr.201600093
2016
Diastereoselective synthesis of furanose and pyranose substituted glycine and alanine derivatives via proline-catalyzed asymmetric α-amination of aldehydes. Ramu Petakamsetty, Anas Ansari, Ramesh Ramapanicker; Carbohydrate Research 2016, 435, 37e49; http://dx.doi.org/10.1016/j.carres.2016.09.011
Stereoselective Synthesis of Hydroxy Diamino Acid Derivatives and the Caprolactam Unit of Bengamide A through Organocatalytic α-Hydroxylation and Reductive Amination of Aldehydes. Anijamol T. Philip, Eerlapally Raju, Ramesh Ramapanicker; Eur. J. Org. Chem. 2016, 5502–5510; https://doi.org/10.1002/ejoc.201600842
Click Chemistry: Mechanistic and Synthetic Perspectives. Ramesh Ramapanicker, Poonam Chauhan; https://doi.org/10.1002/9783527694174.ch1
Synthesis of 1-Deoxy-8,8a–di–epi–castanospermine, 1-Deoxy-6,7,8a–tri–epi–castanospermine and Formal Synthesis of Pumilotoxin 251D. Dr. Shibin Chacko, Dr. Ramesh Ramapanicker; ChemistrySelect 2016, 1, 4458 – 4462; https://doi.org/10.1002/slct.201600891
Controlling Growth to One Dimension in Nanoislands of Ferrocene-Sugar Derivatives. Prithwidip Saha, Khushboo Yadav, Shibin Chacko, Anijamol T. Philip, Ramesh Ramapanicker, Thiruvancheril G. Gopakumar; J. Phys. Chem. C 2016, 120, 17, 9223–9228; https://doi.org/10.1021/acs.jpcc.6b00774
2015
Synthesis of stable C-linked ferrocenyl amino acids and their use in solution-phase peptide synthesis. Anijamol T. Philip, Shibin Chacko, Ramesh Ramapanicker; J. Pept. Sci. 2015; 21: 887–892; https://doi.org/10.1002/psc.2831
Enantiospecific Synthesis of (–)-Cuspareine and (–)-Galipinine. Shibin Chacko, Ramesh Ramapanicker; Journal of Heterocyclic Chemistry 2015, 52, 1902; https://doi.org/10.1002/jhet.2112
Chelation controlled reduction of N-protected β-amino ketones toward the synthesis of HPA-12 and analogues. Shibin Chacko, Mrinal Kalita, Ramesh Ramapanicker; Tetrahedron: Asymmetry 2015, 26, 623–631; https://doi.org/10.1016/j.tetasy.2015.04.016
Click chemistry route to covalently link cellulose and clay. Priyanka Yadav, Shibin Chacko, Gulashan Kumar, Ramesh Ramapanicker, Vivek Verma; Cellulose 2015, 22, 1615–1624; 10.1007/s10570-015-0594-2
Diastereoselective Synthesis of 1-Deoxygalactonojirimycin, 1-Deoxyaltronojirimycin, and N-Boc-(2S,3S)-3-Hydroxypipecolic Acid via Proline Catalyzed α-Aminoxylation of Aldehydes. Shibin Chacko, Ramesh Ramapanicker; J. Org. Chem. 2015, 80, 9, 4776–4782; https://doi.org/10.1021/acs.joc.5b00424
Proline catalyzed, one-pot three component Mannich reaction and sequential cyclization toward the synthesis of 2-substituted piperidine and pyrrolidine alkaloids. Shibin Chacko, Ramesh Ramapanicker; Tetrahedron Letters 2015, 56, 2023–2026; https://doi.org/10.1016/j.tetlet.2015.03.001
Divergent synthesis of various iminocyclitols from D-ribose. Ramu Petakamsetty , Vipin Kumar Jain , Pankaj Kumar Majhi, Ramesh Ramapanicker; Org. Biomol. Chem. 2015, 13, 8512; https://doi.org/10.1039/C5OB01042J
2014
Synthesis of bis-α-amino acids through proline catalyzed asymmetric α-amination of higher homologs of Garner's aldehyde. Ramu Petakamsetty, Ram Pada Das, Ramesh Ramapanicker; Tetrahedron 2014, 70, 9554e9563; https://doi.org/10.1016/j.tet.2014.10.048
A Highly Efficient Catalyst for Selective Oxidative Scission of Olefins to Aldehydes: Abnormal-NHC–Ru(II) Complex in Oxidation Chemistry.
Prosenjit Daw, Ramu Petakamsetty, Abir Sarbajna, Siladitya Laha, Ramesh Ramapanicker, Jitendra K. Bera; J. Am. Chem. Soc. 2014, 136, 40, 13987–13990; https://doi.org/10.1021/ja5075294
2013
Unusual Reactions of the 1,3-Dithiane Derivative of the Garner Aldehyde and Related Compounds. Anijamol T. Philip, Shibin Chacko, Ramesh Ramapanicker; Synthesis 2013, 45(14), 1997-2002; 10.1055/s-0033-1338874
Powerful Binders for the D-Dimer by Conjugation of the GPRP Peptide to Polypeptides from a Designed Set—Illustrating a General Route to New Binders for Proteins. Ramesh Ramapanicker, Xiaojiao Sun, Johan Viljanen, Lars Baltzer; Bioconjugate Chem. 2013, 24, 1, 17–25; https://doi.org/10.1021/bc300186z
2012
Synthesis of γ-Oxo γ-Aryl and γ-Aryl α-Amino Acids from Aromatic Aldehydes and Serine. Shibin Chacko, Ramesh Ramapanicker; Eur. J. Org. Chem. 2012, 7120–7128; https://doi.org/10.1002/ejoc.201201128
Mixed pentafluorophenyl and o-fluorophenyl esters of aliphatic dicarboxylic acids: efficient tools for peptide and protein conjugation. Adam T. Ślósarczyk, Ramesh Ramapanicker, Thomas Norberg, Lars Baltzer; RSC Adv., 2012, 2, 908-914; https://doi.org/10.1039/C1RA00530H
2011
Powerful Protein Binders from Designed Polypeptides and Small Organic Molecules—A General Concept for Protein Recognition. Dr. Lotta T. Tegler, Dr. Guillaume Nonglaton, Dr. Frank Büttner, Prof. Karin Caldwell, Tony Christopeit, Prof. U. Helena Danielson, Dr. Karin Fromell, Dr. Thomas Gossas, Prof. Anders Larsson, Dr. Paola Longati, Prof. Thomas Norberg, Prof. Ramesh Ramapanicker, Dr. Johan Rydberg, Prof. Lars Baltzer; Angew. Chem. Int. Ed. 2011, 50, 1823 –1827; https://doi.org/10.1002/anie.201005059
Applications of Propargyl Esters of Amino Acids in Solution-Phase Peptide Synthesis. Ramesh Ramapanicker, Rohit Gupta, Rajendran Megha, Srinivasan Chandrasekaran; International Journal of Peptides 2011, 854952, 10; 10.1155/2011/854952
2010
An improved procedure for the synthesis of dehydroamino acids and dehydropeptides from the carbonate derivatives of serine and threonine using tetrabutylammonium fluoride. Ramesh Ramapanicker, Roli Mishra, Srinivasan Chandrasekaran; J. Pept. Sci. 2010; 16: 123–125; https://doi.org/10.1002/psc.1210